Healthy Organism

Our computational models simulate both healthy human physiology and various pathological states, with each individual module undergoing extensive calibration against empirical data sourced from the latest clinical studies, cutting-edge biomedical research, and authoritative academic textbooks. The validation process for AIBODY is structured to ensure accuracy and reliability across multiple physiological modules throughout the entire organism, integrated within the software development lifecycle. This approach guarantees that each module performs optimally in isolation.
Additionally, the engine's responsiveness to dynamic inputs, such as pathological states or therapeutic interventions, is rigorously tested to confirm its robust predictive capabilities. The integration of these physiological modules is validated through thorough system-wide calibration conducted after each deployment, ensuring that interactions between different physiological components are accurately depicted and function cohesively.

Vitals

Parameter NameOrganism ValueReference ValueUnitDeviation %Reference
Heart Rate7260 - 100BPM0.0Mason JW, Ramseth DJ, Chanter DO, Moon TE, Goodman DB, Mendzelevski B. Electrocardiographic reference ranges derived from 79,743 ambulatory subjects. J Electrocardiol. 2007 Jul;40(3):228–34.
ABP Systolic121.5119.9 ± 15.9mmHg0.0Lin JD, Chen YL, Wu CZ, Hsieh CH, Pei D, Liang YJ, et al. Identification of Normal Blood Pressure in Different Age Group. Medicine. 2016 Apr 8;95(14):e3188.
ABP Diastolic7375.3 ± 10.9mmHg0.0Lin JD, Chen YL, Wu CZ, Hsieh CH, Pei D, Liang YJ, et al. Identification of Normal Blood Pressure in Different Age Group. Medicine. 2016 Apr 8;95(14):e3188.
CVP10.58 - 12mmHg0.0Shah P, Louis MA. Physiology, Central Venous Pressure. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Nov 18].
SpO29894 - 98%0.0O’Driscoll BR, Howard LS, Earis J, Mak V. British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings. BMJ Open Respiratory Research. 2017 May 15;4(1):e000170.
ET-CO23735 - 45mmHg0.0Greenbaum H. Emergency Capnography. 1st ed. Boca Raton: CRC Press; 2024 [cited 2024 Nov 21].
Tidal Volume490420 - 560mL0.0Poole J, McDowell C, Lall R, Perkins G, McAuley D, Gao F, et al. Individual patient data analysis of tidal volumes used in three large randomized control trials involving patients with acute respiratory distress syndrome. Br J Anaesth. 2017 Apr;118(4):570–5.
Respiratory Rate1911 - 20BPM0.0Natarajan A, Su HW, Heneghan C, Blunt L, O’Connor C, Niehaus L. Measurement of respiratory rate using wearable devices and applications to COVID-19 detection. NPJ Digital Medicine. 2021 Sep 15;4:136.
Mean Arterial Pressure (MAP)89.270 - 100mmHg0.0Roberts JR, Custalow CB, Thomsen TW. Roberts and Hedges’ Clinical Procedures in Emergency Medicine and Acute care, 7th edn. Philadelphia (PA): Elsevier, 2018, pp. 1529–1541.
Cardiac Output7.16.57 ± 1.19L/min0.0Boland J, Gazibarich G, Wang L, Muller D. Importance of Valid Reference Ranges for Cardiac Output-Derived Haemodynamic Variables. Heart, Lung and Circulation. 2017 Jan 1;26:S137

Amino Acids

Parameter NameOrganism ValueReference ValueUnitDeviation %Reference
Gly (Glycine)207.2120 - 540μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Ala (Alanine)417.9210 - 661μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Val (Valine)256141 - 317μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Leu (Leucine)160.975 - 175μmol/L0.3Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Ser (Serine)160.765 - 193μmol/L3.5Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Asp (Aspartic acid)4.3 < 24μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Glu (Glutamic acid)25.714 - 192μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Asn (Asparagine)60.530 - 69μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Gln (Glutamine)653.6396 - 711μmol/L0.3Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
His (Histidine)61.632 - 107μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Lys (Lysine)151.983 - 238μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Arg (Arginine)45.921 - 138μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Cys (Cysteine)67.833 - 117μmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Met (Methionine)13.46 - 40μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Phe (Phenylalanine)71.348 - 109μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Trp (Tryptophan)47.920 - 95μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Pro (Proline)192.958 - 324μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.

Vitamins

Parameter NameOrganism ValueReference ValueUnitDeviation %Reference
Folate (B9)13.35.2 - 29.2nmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Cyanocobalamin (B12)267133 - 595pmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Thiamine (B1)189.974 - 222nmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Ascorbate (C)56.523 - 85μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Cholecalciferol (D3)102.721 - 116pmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Tocopherol (E)31.712 - 42μmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.
Phylloquinone (K1)2.50.29 - 2.64nmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019. Chapter 18, Amino Acids, Peptides, and Proteins; 301 p.

Hormones

Parameter NameOrganism ValueReference ValueUnitDeviation %Reference
Testosterone21.710.4 - 41.6nmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2017.
Cortisol188.5138 - 690nmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Aldosterone0.180.19 - 0.83nmol/L5.3Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Prolactin0.480.4 - 3.1nmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Insulin74.317 - 153pmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2017.
Estriol3.5 < 69nmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Calcitonin0.61 < 70pmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Glucagon21.55.74 - 28.7pmol/L0.0Rifai N, Horvath AR, Wittwer CT. Tietz fundamentals of clinical chemistry and molecular diagnostics. 8th ed. St. Louis, MO: Elsevier; 2019.
Vasoactive intestinal polypeptide0.96 < 15.03pmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.
Vasopressin3.80 - 5.4pmol/L0.0Ph.D. Laposata, Michael, M.D. Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory. 2nd ed. New York, NY: McGraw-Hill Education; 2014.

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