Navigating the Landscape of Digital Twinning Technologies

Today's landscape of human digital twinning is evolving and brings a wide array of different technologies and approaches. In its essence, a digital twin involves creating a digital replica of a physical entity. Simulation in industry is not a new concept; NASA has been creating digital twins since the Apollo 13 mission1.

In healthcare, the scale of the model and interactions are more complex, but the aims are the same: to prevent disease and monitor patients more effectively. We create detailed models of patient-specific pathophysiology that can interact and respond to new input data as it arises. This technology holds immense potential for personalizing and enhancing patient care in a safe environment, enabling doctors to predict outcomes, plan and monitor treatments, and understand complex medical conditions much more effectively. 

At one extreme, we see traditional models dominating the space, particularly in physiology engines2. These models, based on a top-down approach, are used throughout medical education, providing trainees with a foundational understanding of human physiology in the context of simulated scenarios. However, their application to clinical practice is limited. The top-down approach to these models, alongside their inability to adapt to the unique physiology of individual patients, restricts their utility.

On the other end of the spectrum, we find ambitious research and development initiatives aimed at constructing highly detailed models of human physiology. These models are characterized by their complexity and the inclusion of millions of parameters3. Yet, their application in everyday healthcare is hindered by the immense computational power required to run these models in real-world clinical settings. This makes them currently impractical for widespread clinical use.

There is a need for practical, scalable digital twinning solutions in healthcare that work in a fast-paced environment. AIBODY's approach is to strike an optimal balance between specific digital twin models and usability. We take 2D trans-thoracic echocardiogram data and produce anatomically accurate patient-specific models combined with a tailored haemodynamic model unique to the patient. 

One of the standout features of AIBODY's digital twins is the simple integration into existing clinical workflows by providing access to our digital twins through the web browser. In the fast-paced environment of a hospital, where time is of the essence, it is essential for any healthcare technology application. AIBODY leverages simple diagnostic methods that clinicians can readily access, ensuring that the adoption of our digital twins doesn't disrupt existing processes but rather enhances them.

The digital twin approach, performance, and integration simplicity of AIBODY's solutions are what set us apart. By focusing on these aspects, we ensure that our digital twins are not just theoretical models but practical tools that clinicians can use to make informed decisions, tailor treatments to individual patient needs, and ultimately improve patient outcomes.

We are excited to see where the future of digital twins takes us; at AIBODY, we are at the forefront, bridging the gap between theoretical models and practical clinical applications. Our digital twinning solutions represent a significant leap towards a future where personalized, data-driven healthcare is not just a possibility but a reality.

Dr Aaron Smith
Chief Medical Officer
MBChB BSc MRCP

References

1. Allen BD. Digital Twins and Living Models at NASA [Internet]. [cited 2023 Dec 4]. Available from: https://ntrs.nasa.gov/citations/20210023699

2. Bray A, Webb JB, Enquobahrie A, Vicory J, Heneghan J, Hubal R, et al. Pulse Physiology Engine: an Open-Source Software Platform for Computational Modeling of Human Medical Simulation. SN Compr Clin Med. 2019 May 1;1(5):362–77.

3. Vázquez M, Arís R, Aguado-Sierra J, Houzeaux G, Santiago A, López M, et al. Alya Red CCM: HPC-Based Cardiac Computational Modelling. In: Klapp J, Ruíz Chavarría G, Medina Ovando A, López Villa A, Sigalotti LDG. Selected Topics of Computational and Experimental Fluid Mechanics. Cham: Springer International Publishing; 2015. p. 189–207.

Introducing Nova Heart: A Milestone Innovation for Cardiology Care

Greetings,

We are thrilled to unveil Nova Heart, our revolutionary cardiology-centric digital twinning solution, developed in collaboration with the renowned German Heart Center at Charite (DHZC). This groundbreaking technology stands at the cusp of significantly transforming patient care and monitoring approaches for structural heart diseases.

Innovative Approach:

Nova Heart creates a dynamic digital twin of a patient’s heart utilizing 2-D transthoracic echocardiogram data. It amalgamates an anatomically precise 3-D model with a sophisticated intracardiac hemodynamics model. This model computes heart chamber volumes, pressures and cardiac output in real-time, aligning with the specific patient parameters.

Intuitive Patient Reports:

Nova Heart synthesizes pivotal echocardiographic parameters within coherent patient reports. These reports not only highlight anomalies and key trends in parameters but also empower clinicians with swift access to and comprehension of the most clinically pertinent information, saving them a significant amount of time and enhancing their ability to make informed decisions regarding patient care.

Immersive Learning & Simulation Platform:

Beyond its clinical applications, Nova Heart serves as an immersive learning platform for medical professionals and students. It allows users to simulate diverse cardiac pathologies, modify physiological parameters, and observe real-time alterations. The advanced 3D visualization, real-time data manipulation, and a comprehensive patient information repository let users interactively engage with virtual patients, transcending conventional textbook learning.

Broad-Spectrum Applications:

While our inaugural applications are centered around congenital heart disease pathology, the versatility and non-invasiveness of Nova Heart position it as a favorable candidate for widespread acceptance among cardiologists. It provides a seamless blend of precision medicine, augmented visualization, meticulous treatment planning, and proactive patient monitoring & engagement, all aimed at cost-effectively optimizing patient outcomes.

Engage with Nova Heart:

We warmly invite you to explore the diverse possibilities Nova Heart offers. Contact us for a demo and delve deeper into how Nova Heart can elevate the capabilities of you and your team in delivering unparalleled cardiology care.

Warm Regards,

Dr Aaron Smith
Chief Medical Officer
MBChB BSc MRCP

AIBODY at the 18th Annual Lange Symposium in Berlin

By Kiril Tasseff

This past weekend, our team had the exceptional opportunity to both attend and exhibit at the 18th Lange Symposium, a renowned conference in Berlin organized by DHZC. A mecca for thought leaders in pediatric cardiology, obstetrics, and neonatology, this year's focus was on the intricate subject of Ebstein's Anomaly—a rare and complicated congenital heart defect that has been a perpetual obstacle for cardiologists around the world.

Insightful Conversations and Cutting-Edge Approaches

What set the symposium apart were the in-depth insights shared by luminaries in the medical field, specifically on the evolving strategies concerning the diagnosis, treatment, and management of Ebstein's Anomaly. The expert-led presentations delved into the nuanced decisions clinicians must make in areas such as treatment versus repair, optimal timing for surgical interventions, state-of-the-art surgical techniques, and the handling of comorbid conditions.

Advancements in Imaging Modalities

One segment that captivated our attention was the discussion on the pros and cons of various imaging techniques like echocardiography (Echo) and magnetic resonance imaging (MRI). These modalities play different roles at different stages of diagnosing, planning, and treating conditions like Ebstein's Anomaly. Due to its non-invasive nature, cost-effectiveness and wide availability, the Echo already serves as an indispensable instrument for cardiologists. We believe that with the advent of next-generation digital twinning technologies, like our proprietary Nova Heart (see more below), Echo can become even more prominent and assume an increasingly pivotal role in shaping care pathways for patients with cardiac conditions.

Unveiling Nova Heart: A Game-Changer in Cardiology

The conference also served as the perfect platform for us to introduce Nova Heart to the global medical community. The response surpassed our expectations; clinicians from around the world expressed immense interest and provided invaluable feedback. Nova Heart, designed to integrate seamlessly with a physician's workflow, embodies the future of digital twinning technologies. The resounding demand for such capabilities validated our product's relevance and impact.

Nova Heart in Action

Moreover, it was an honor for us to see some of the speakers utilize Nova Heart as an illustrative tool during their presentations. This not only showcased the technology’s practicality but also helped to elucidate various aspects of Ebstein's Anomaly to a wider audience.

As we reflect on our experience at the 18th Lange Symposium, we are grateful for the shared knowledge, professional growth, and promising partnerships that transpired over this extraordinary weekend. We eagerly look forward to contributing to future dialogues and pioneering advancements in the field of cardiology.

Warm regards,

Kiril